“The H. Pylori Paradigm” offers a comprehensive, up-to-date account of the bacterium Helicobacter pylori — covering its microbiology, pathogenic mechanisms, and clinical management. Written for paramedical and microbiology students (as well as clinicians and researchers), the book delves into how H. pylori survives and thrives in the acidic environment of the stomach. It explains in detail the organism’s motility, adhesion to gastric epithelium, urease production (which helps neutralize stomach acid), and other virulence factors that enable colonization and persistent infection.
Dr. Rastogi also discusses the clinical significance of H. pylori infection: chronic gastritis, peptic ulcer disease, and the increased risk of gastric cancer and MALT lymphoma in some individuals — outcomes that depend on a complex interplay between bacterial virulence, host immune response, and environmental or genetic factors. The text reviews both invasive and non-invasive diagnostic methods (endoscopy with biopsy, urea-breath test, stool antigen, serology, etc.) and outlines current treatment strategies, including antibiotic regimens, and the challenges posed by emerging antibiotic resistance.
Overall, the book bridges basic microbiology with clinical practice; it helps readers understand how laboratory findings translate into diagnosis and therapeutic decisions — making it a valuable reference for students, microbiologists, gastroenterologists, and anyone interested in the biology and management of H. pylori infection.